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ƫͷʹһм巢ԷΪԵƫಫͷʹġŻ¼һЪںٴηڰڰڻ˯ߺͷʹ⡣ͷʹǰʱɰ񾭡ϰ

(һ)ԭ

ƫͷʹȷв򼰷Դ֮Сܶؿշػ򻺽ƫͷʹķͨѧķѧҲһЩѧ˵

ijЩԣܶⲿڲı仯ɼƫͷʹ

1.ر仯 ڷҩƫͷʹƵ;¾ƫͷʹĴ(“ͷʹ”);Խɴƫͷʹ(“Խͷʹ”)

2.ijЩҩ ijЩ׸иƽ(ʹ)ɽ(ʹ)ͺɳֵ͵ƫͷʹ

3.仯 رתȡƻʪ

4.ijЩʳӼ ǾƾϣijЩѾ;ƷңرӲ;;εʳȹ;ijЩˮˮ;ɿ(“ɿͷʹ”);ijЩ߲;ĸ;˹ʳ;͵Ʒݲ;ζ

5.˶ ͷ΢С˶շƫͷʹʹ֮أЩ³˳ƫͷʹҳ˳;ͷշͷʹ(“˶Աƫͷʹ”);¥¥ɳƫͷʹ

6.˯߹١

7.һٷ©Իӡ

8.̻С

9.⡢ƹǿ

10.š䡢(“ͷʹ”)ܶŮԹ̳˶ijϿƫͷʹ;ʱӵ1minҲʹƫͷʹء

ڼУüӦǡи壬һƬӿܲͷʹöͷʹЩ£öҲͷʹͬʱ¾Ӱ죬þͿƫͷʹеĸ̳дһַеĸ̳оôųƫͷʹ

ƫͷʹкܶءƫͷʹʱƬ̣ʹͷʹ⡣ڹ߽ϰķĿʹͷʹ⡣ͷʹʱϲ˫ѹ˫࣬ʹͷʹ⣬ͨˮϴͷʹͷʹԻ⡣Ů3ºƫͷʹڻ⡣

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йطƵļѧ˵

1.Ѫܻ5-HTѧ˵ ѧἰһǷƫͷʹѪС5-HTŨ½5-HTл5-HTӡ

Ը5-HTԪȥԪɵ­Ѫܶ5-HT׿ҩƫͷʹЧѪƽĽ5-HTɼƫͷʹ

2.ѪĤӦ ̼ͨݶ񾭣ʹĤԷӦƫͷʹҩǰ˫ǰ ̹(sumatriptan)ȿֹԴ֢

ƫͷʹ߿ɼ⵽ͷŵĽػ(CGRP)ػΪǿҵѪҩ˫ǰSumatriptanܻͷʹܽͽػĺˣƫͷʹʹѪ֢޾ĤסWilkinsonΪ񾭷ֲʹƫͷʹܾһԴ֢Solomonڸϰͯƫͷʹо׺ָͯۼƫͷʹĸӣԴںھڶͰڢ񾭵𺦡һֽС϶ʹԺɵĵڢ񾭵𺦣ҲΪ񾭵֢

3.Դʹϵͳϰ ˮΧҵ׻ʺдʹйصԴ԰ƬʣԷġβ-ڷ߾ȡ£ЩͨʹĵڶʹáȻĽһʾƫͷʹԼҺѪβ-ڷĻオͣʾƫͷʹߴԴʹϵͳϰϰ»ʹֵͣʹǿڷʹٸƽƫͷʹͬʱѪβ-ڷˮƽߡ

4.ϰ ϰ缴ѧǵӡ˲ʱʱ켰Ѫܷоʾƫͷʹߴڽйܵ¡24h̬ʱоʾƫͷʹߴڽСйƽϰҲѧ߱ƫͷʹߴֱͫʾⲿֻߴ쳣Ϊƫͷʹеϰйء

5.ƫͷʹļۼԼо ƫͷʹ߾п϶ļۼŴԣоҲ϶Ǽƫ̱ƫͷʹƫͷʹƫͷʹƫͷʹиߵļۼԡƫͷʹƫ̱ͬһ彻֣ͬʱڼУڴˣѧΪƫ̱ƫͷʹͷǸƫͷʹܾͬIJͲBalohȱ壬жԱƫͷʹʵͷʹѣηԭе̷ΧǰͥɥʧеļԱһ£25ǰ֢״

бƫ̱ƫͷʹȱ19Ⱦɫ־йأҲзʾеƫ̱ƫͷʹ19Ⱦɫ޹أʾƫ̱ƫͷʹڻı졣19Ⱦɫйصļƫ̱ƫͷʹַ߳ʶϰƵȽϸߣʾڸ19ȾɫйصƫͷʹⲿշֵϵŴġOphoff3419Ⱦɫйصļƫ̱ƫͷʹ壬ڵѹբԸͨα1ǵλ빦4ֲͬĴͻ䡣

һְзļԷԹʧǹʧѣΰԷΪŴ񾭹ϰ໼Լ50%ƫͷʹٴ֢״ƫ̱ƫͷʹصƫͷʹĵ״̬йأҾԭ𼰽ԹʧOphoff2зļԹʧ壬19ȾɫѹԸͨͻ䣬ڼƫ̱ƫͷʹ̽⵽һͬĶܱϣһֽضϵα1ǵλ⵼¿Сڴĸͨܶȵļ٣ɴ˿ܽ䷢ԼԼصĹʧͬĴͻε¼ƫ̱ƫͷʹеƫ̱в

Baloh3˫ǰͥļƫͷʹ塣жԱƫͷʹͷʹѣη()̷ǰͥɥʧڣѣηֹͣ˫ǰͥɥʧƽϰ·ڶǰͥëϸϸͨǵλͻõѡԵıɴ˽ʱѣκͽ˫ǰͥ䡣

6.Ѫܾѧ˵ ­Ѫſɰе͵ƫͷʹͷʹƫͷʹǷ­Ѫܵľ顣ΪƫͷʹӾѪܾģȷе֤ݱƤԪҶҶ(3mm/min)ɵġѪܾθĤƫͷʹʼԭһЩ߾ݵĵʧڷڼ飬ɷĤľΡ⣬Щ߶ԿѪܾμзӦƫͷʹصɥʧ()ѣοɻϺ()ǰ֧ͥѪܾ͡Ѫܾοɵܰ͹ܻҵȱѪ𺦣ܰҺѭ𺦣շչΪˮס­(TCD)ѪٶȲⶨ֣ƫͷʹڻǷڣѪٶȵļӿ죬ʾⲿֻ­ѪܽŶߡ

7.ͨϰ ܶƫͷʹۺеٴŴͨϰйءƫͷʹڶھֲϸصĻۡƽԪʱ˳ΪڶͨάָصܰͺԪ˷ܹܷҪģԺڶͨȱݿɵ¿ëϸǰ֢ͥ״ƫͷʹеͷʹǼ̷ϸŨӵĽƫͷʹۺĺܶշأš¾ǼضȱݵĸͨӰĽ

8.ѧ˵ ˷ƫͷʹڷڴѪСԷۼӡ˷ƫͷʹߴTXA2PGLI2ƽϰPʼ񾭼ĵĸı䡣

֢״

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Ůռ2/3, 10ǰ20ǰ40ǰֱΪ25%, 55%, 90%ƫͷʹʷǰСʱ ǰ֢״Ż¡η⡢η뵡, 10%ĻӾסƵÿÿ1βȣżгԷ

SaperƫͷʹʱΪ5ҪָǣڲÿηرģеĻ߿ֻеڣߵķΪ2ڻ2ϣеĽеһڡһ棬ÿԴںܴͬͬһķҲɲͬ

1.ǰ 60%ƫͷʹͷʹʼǰСʱǰ֢״ǰ֢״ףƫͷʹƫͷʹɳǰ֢״ɱΪı䣬羫ƣɢ˯Ҳ׼ǡǡķеȡпɱΪ֢״ɫ԰ס䡢ʳԵļСڿʡ١ƵǷӲġ䶯ӡʹкĻš̡ʼӿ죬ζеȡͬǰ֢״кܴIJ죬ÿÿηǰ֢״ȶԡЩǰ֢״ǰڳ֣ҲͷʹСͷʹΪ֢״

2. Լ20%ƫͷʹ֢߳״׶Ϊ֢״żΪȫ񾭹ϰ͵Ӧ4е3ظ֣𽥷չʱ䲻lhͷʹ׳520min׿ͻȻҲеĻͷʹڼ֢״аǨ׵ƫͷʹײʼͷʹ֮ǰпɳͷʹСʱ7졣

׿ΪӾԵġ˶ԵġоԵģҲɱΪԸɻСԹϰΪӾףԼռ׵90%硢㡢ۺڲ˫ۺڲΡҰհ׵ȡΪ⡢Ƕ⡣Ĥƫͷʹ۵׿ɼĤˮףżɼӣɫưߡӾijΪԡ͵Ӱһֺ沿Ҳɳƫ̱ưۣɳʧʮӺֶԲͬͷʹڶͯڷΪƫ̱ƫͷʹƫ̱ƫͷʹߵľɳ7ϣӰѧϷԹƫͷʹǨ׺ƫͷʹƫ̱ǰ“ƫͷʹ”ƫͷʹ˶ϰΪۼƫͷʹΪ£Ϊ񾭺չԡƫͷʹʷԿɾò漰ԸɻСԣ״Ϊƫͷʹֳƻ׶ƫͷʹɳͷ衢ѣΡϰʧӣӾ֢״⡢㡢ڲҰȱΡ˫𺦿ɳʶƣȼڶͯпɳָоٶۣƫоϰȡ

ƫͷʹ׿ɲͷʹ֣Ϊƫͷʹλ֢ڶͯƫͷʹʱԺ׿ΪƫͷʹҪٴֶͷʹͷʹҲͷʹ֣ɱΪ⡢㡢ʹкġŻ¡ѣΡƫ̱ƫľı䡣ͯԷѣΡǰͥ÷ᰣԸѣΡиоʾΪٵΪ÷ᰣĻߣ֢״ƫͷʹйءбһԸѣλߣ755֮䣬𷢲֢״ΪͷΡġŻ¼󺹣34첻ȡʼĩڱΪλѣΣڼ֢״ڼл߾֢״Щѣηƫͷʹżͬƾ˯߲㡢ɼأŮԶ෢ھڡ

3.ͷʹ ͷʹɳΧͷ򾱲κβλλࡢΪʹҲΪ˫ʹչΪȫͷʹеʹԼռ2/3ͷʹΪʹҲеĻΪʹʹ̶ΪСضʹܡdz󷢲𽥷չ߷𽥻⡣ҲеĻ𲡣ͷʹʱ4h3죬ͯͷʹʱ2h2졣гʱߣɳܡ˽3ϵƫͷʹΪƫͷʹ״̬

ͷʹڼ䲻ٻֶ߰ġŻ¡ﲻ塢η⡢ηȣϲӡΪ֢״һϣҳΪСضȶġĿͷʹҲͷʹл֡һĻ߳Ż£ЩߵľŻºԻ⡣ϰҲɳ֣ƵϰĻšѪѹѪѹɳʧۼԸɻС߿ɳѣΡʧӡ½ʶϰ

4.ͷʹĩ Ϊͷʹʼֹͣһ׶Ρ

5.֢״ ΪٵĻͷʹһϵк֢״ֵ롢ۡ˯еĸоƣߡлʳͷƤѹʹʹҲɳ־ı䣬緳ꡢŭľǻ䡢ٶȡ

6.ͯƫͷʹٴ ͯƫͷʹǶͯͷʹijͯ͡ƫͷʹƫͷʹһЩͬԱ棬ഺǰƫͷʹŮ߱ȣƫͷʹŮԱӣԼΪԵ3

ͯƫͷʹշкܶƫͷʹһ£ۺſշͷʹΪٵĶͯ˶շͷʹͯƫͷʹ߿˯ϰϺȾԼڶͯȳ˸ʹͷʹء

֢״棬ͯƫͷʹƫͷʹ𡣶ͯƫͷʹʱ䳣ϳ˶̡ƫ̱ƫͷʹڶͯڷֹͣƫ̱ɴһൽһ࣬͵ƫͷʹѿơƫ̱񾭹ȱ𣬲ɳֲҲ֪ϰ׶ƫͷʹڶͯҲȳ˳⡢㡢ģҰȱҲɳԸɡСԼ֢״ѣΡڶͯʶ߱ȳ˶࣬пɳֵЩƫͷʹͯпɽַѣΣͷʹһƽʱȫĶͯͻȻ־塢Сɫ԰ס󺹡̬ǡѣΡתУӺȫ⣬ָ糣֮ΪͯԷѣΣһƫͷʹλ֢ѣη͵ʼ4ǰÿη𽥼٣78Ժٷ˲ͬͯƫͷʹǰ֢״Ϊʹʱƫͷʹ֮ԸʹġŻ¡кΪƫͷʹλ֢ƫͷʹİ֢״УͯƫͷʹŻ½ϳ˸ӳ

ͯƫͷʹԤϳƫͷʹá6ԼһͯپƫͷʹԼ1/3ƫͷʹõơʼഺԺijƫͷʹʮꡣ

ƫͷʹӦϸIJʷرͷʹʼص֢״dzҪͷʹIJλʡʱ䡢ʹس̶ȡ֢״IJʷշصȡ

ƫͷʹӦϸµһڿƲ弰񾭿Ƽ飬Գ֢״ƫͷʹصƻͬʱڵƫͷʹȻûԵʵָ꣬ʱ軼߱ҪʵҼdzҪѪԼҺӰѧ飬ųԲ䡣رڳֵͷʹӦųԲ䡣ص׻ʱӳʱѧ߽­CTMRI顣Ҳѧ鵱ƫͷʹÿ³2ʱӦƫͷʹԭ

ͷʹЭ(IHS)ͷʹίԱ1962ƶһͷʹϱ׼ɵķϱ׼緶ΧӦ20꣬ҹвѧרûοࡣ1988ͷʹЭͷʹίԱƶµĹͷʹʹ沿ʹķϱ׼Ŀǰٴж׼׼ͷʹΪ13Ҫͣ129ͷʹ͡гͷʹΪƫͷʹͷʹԼͷʹԷƫͷʹƫͷʹֱΪ7(14)7УҪ2ƫͷʹƫͷʹƫͷʹ

 

 

 

 

ͷʹЭϱ׼Ϊƫͷʹṩһɿġϱ׼ٴͿеԶ׼ģѧرᵽٴ鼰вѧҪ塣ٴʱ߲ȫ׼ѧǽü飬ȷϡ

ڹͷʹЭϱ׼ȽϸӣΪ˱ٴӦãһЩ֪ѧһֱ̽һּ򵥻ϱ׼Solomonһ׼򵥱׼׼Ļ99%ϹͷʹЭƫͷʹϱ׼ױ׼գοپ߱4еκ2ƫͷʹA.ʹλڵ(˫);B.ʹ;C.(л򲻰Ż);D.ηη˵A.״η߲Ӧ;B.ӦԼ֤ݡ

ٴʱΪͷʹʱΪƫͷʹʵͷʹȲ˹һЩٴо׺õĴǣͷʹƫͷʹǽȻֿģٴȷʵصѧ߿һͳһ塣ʱƫͷʹ߿ɱΪƫͷʹͬѧΪ֮ȿвͬIJֿһͳһ塣

1.Եͼ飺һΪƫͷʹڷڻЪڣԵͼ쳣ʽԱߣǣƫͷʹ˵Եͼı䲻ԣΪΡͨŵ硢ԼನԼԹ̼ͨ쳣ӦȸֲΡСƫͷʹԵͼ쳣ʽϸߣ9%70%ȣɳּ첨

2.Ѫͼ飺ڷںͼЪѪͼҪ仯ನԳƣһƫ߻һƫ͡

3.ѪӰ飺ԭƫͷʹ˲ѪӰֻصͷʹ߶ȻǷΪĤǻѪIJ˲ŽѪӰڳ­ڶεȼɣƫͷʹѪӰġ

4.ԼҺ飺ƫͷʹԼҺijͨģһԼҺܰϸߡ

5.ѧ飺һΪƫͷʹ˵򵰰IgGIgAC3Eγɿɽƫߡ

6.ѪСܼ飺ƫͷʹ˵ѪСۼԿߡ

1.ͷʹ ֳƼͷʹٴصǣͷʹλɢλǰ˫򨡢ͷʹʳʶʹͷѹȸСУ߳һñӡͷʹʳԣʱʱءͷƤѹʹ㣬Ħͷʹͷʹ⣬жšٰжġŻ¡

2.Լͷʹ ֳ鰷ͷʹHortonۺΪһϵܼġݵġصĵʹƫͷʹͬͷʹλ޲̶һͶ򨲿ʱ䳣ҹ䣬ʹʹѡʱ̶ͻȻףʼΪһDzƸлѹȸУ֮ضλʹʹ̣沿죬ĤѪᡢ顢ΪٵĻ߳Hornerɳη⣬ġŻ¡ΪȺơ˷ܻѪҩ𡣷䳣ƫͷʹƽ25꣬Ů֮Լ41ʷ

3.ʹۼ ֳTolosa-HuntۺһͷʹۼΪ漰طۿͺԼΪ­ھڶķ֢Ҳ漰񼡣Ϊ󼰿ܵʹʹָܺӣеڢ󡢢۱֣󸴷ѪӰųڶƤ̴Ч

4.­ռλͷʹ ռλڣͷʹΪԻΪأŲķչΪͷʹԼأɳ­ڸѹ֢״ͷʹġŻ¡ˮףɳ־֢״羫ı䡢ƫ̱ʧƫоϰ鴤ƫäʧȣ߼ѡע⣬ҲбΪʮƫͷʹȷΪ޴Ѫߡ

5.ѪͷʹѪѹѪѹδ­ڶ򶯾ΡӲĤѪ׵Ⱦƫͷʹͷʹ, ֲо﷢֪ϰ­CTMRIDSAʾ䡣

6.ƫͷʹԹ, ƫͷʹɼ̷ȱѪУƫͷʹԲ̺Է2ص

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Ϊ֢״һϣҳΪСضȶġĿͷʹҲͷʹл֡һĻ߳Ż£ЩߵľŻºԻ⡣ٻ߻ɳﲻ塢ηηϰƵϰĻšѪѹѪѹɳʧۼԸɻС߿ɳѣΡʧӡ½ʶϰȡ
ͷʹɳֵ롢˯еĸоƣߡлʳͷƤѹʹʹҲɳ־ı䣬緳ꡢŭ䡢ٶȡ

Ԥ

ؿշƫͷʹעЩضϮӣʳ־һ̶ȿԤƫͷʹ

(һ)ƫͷʹ

1עӰ죬硢ʪȡ꣬ҫ۵⣬䡢仯շƫͷʹעܷ纮ůҪɹֹ꣬շ²

2ע˯ߣ˶͵Ӱ죬עɵ˯ߣ˶ǿƻԣԣעݽϣע۾ڣв˵ҪԤʩ

3עͨ磬̾ơ

4עҩӰ죬շƫͷʹҩҩͣ֯Ѫƽ±ຣƼأVitAȡ

()ƫͷʹʳ

1ƫͷʹʳҪǣ

(1)Ұʳ翧ȣɿƷ

(2)֬շƫͷʹռȫʳص49.8%ϸƴΪʳɷֹƫͷʹ

(3)ƾϣرǺɫѾƣ׾ƣ֭٣ܵȡ

(4)ţ㳦Ʒ͵ȡ

2ͷʹʳԭ

(1)ʵ֢ͷʹʳ嵭ףʳ⣬ɶʳˣˮʳ

(2)֤ͷʹɶʳӪʳĸ⣬ΣԼԲȡ

(3)ߣ˳߲ˣˮ̶ඹȡ

(4)̡ƺ͹зϺȷ

()ƫͷʹĸ廯ҩ

ƫͷʹԤӦ廯رǼĸ廯ɸݻأһҩѡʼ𽥼Ըãҩ23죬Чʱٽҩ

1.鰷ҩ ΪһЧƫͷʹԤҩ2/d0.5mg/𽥼һ3/d1.0mg/Σ6mg/dΪ˯ͷ衢ӵȡ

2.ͨ׿ҩ ຣÿ1Σ510mg/Σ˯׶ϵӦӡȡ

3.β-ҩ ʼ3/d10mg/Σ60mg/dҲн120mg/d<60/minͣáطҴ߽á

4.ҩ 3/d25mg/Σ𽥼˯ȸãԡ͡(ҹƷǽ)20mg/ƬÿlƬҩʼЧͬ÷㣬˯ϰθ֢״ȣᡣ

5. ҩ;ҩ翨ƽƵ;ؼ̩;ҽҩ(֤ʩΡ澭ʩΡɷӼгҩ)ȽԿá

(һ)

SaperƫͷʹķνйٶȨIJҪοSaperĹ۵㲢KlapperWilkinsonSilbersteinѧߵĹ۵нܡ

1.һԭ ƫͷʹƲ԰棺֢ƼԤơ֢ƵĿƻʹ֢״ԤͷʹƵȼͷʹԡƫͷʹǵö֢ƻͬʱȡ֢ƼԤƣҪһ˵ͷʹƵȽСʹ̶Ƚᣬʱ϶̣ɿǵѡö֢ơͷʹƵȽϴʹ̶ȽأʱϳԹѧϰӰԣڸ֢ƵͬʱʵԤơ֮ҪǵʹԻߵӰ죬Ҫǵҩ︱öԻߵӰ죬ʱҪο߸˵SaperĽÿܷ2ߵҩԶ֢ƣƵӦԤơ

Ƕ֢ƻԤƣ棬ҩԤҩԤҩԤ棬ǿϸ¼ǰ֢״ͷʹʱ估֢״ҳͷʹշأɱ⡣ijЩʳֹɵϢʱ䡢ʳڹգĩֻڣЩڼͷʹdzҪЩ30%а˳йɵĶ糤ܵȣЧؼͷʹ֪ΪƣﷴƵȣѱ֤ЧлͷʹʱʹѹȣˬĻжԱһЧ

2.ҩ֢ ƫͷʹ֢ƿѡ÷ҩƣ򵥵ֹʹҩʧҩҩᡢжͷʹ򵥵ʹҩҩɻͷʹķõҩв(Ƭ)(Ϣʹ)˾ƥ֡(ʹ)ҡͨ(­ʹ)ȡҩӦϸƵģSaperҪطƲܻ⣬ƫͷʹнɻܵӦáƫͷʹ5-HT׿ҩҪСضƫͷʹƫͷʹ5-HT׿ҩϼ򵥵ֹʹҩͷʹɵõЧơ

5-HT׿ҩƫͷʹЧǿ϶ġǰȥصȡ׿β-Ľϣڻͷʹʼ1ƬʹͷʹֹᡣЧԣСʱӷ1Ƭÿ첻4Ƭÿ10ƬҩȱǸý϶࣬гԣʱԽԽ󡣳Ϊ֢״Ѫ֢״ġŻ¡ơ̵ȡиļȱѪѪѹȼá

ǼʯǰSumatriptan˫ǰ(ǰ)ΪƫͷʹҩΪ5-HT׿ҩЩҩϵͳ鵼ͨ·ͨԴ֢𵽿ƫͷʹá

ǰ(ʯǰ)ҪСضƫͷʹرǵ򵥵ʹЧʱжã5-HT1A5-HT1B5-HT1D5-HT1F׿ҩα-׿ҩ̼ͨƽϸ5-HTѪ;ѪܡƽĩȥȡΪ5-HT׿ҩѪϵͳԴ֢俹ƫͷʹĻƿڴˣѪá񾭵ʵöԻƫͷʹҪġҩ;пڷ¼ֱҩöҩ;ϵСڷºղȶֱҩЧ죬տɿΪ˼ٹӦõǰԻͷʹһÿӦò2ΣӦҩ

Saperܽʯǰûã5560(Խ);;Ķ(ض);Ҽ(ض);ԭ-ⲡ;ļ;IJѪܾĽʹ;Ѫѹ(ض);л;Ρ(ض);Ⱦ/Ѫ֢;Լ;ΧѪܲ;⣬ҩɼƫͷʹɵĶġŻ¡

sumatriptanСضƫͷʹѪϵͳϵͳͨƻԴ֢á˳sumatriptanΪƫͷʹƵ̱Ƥҩ2hԼ80%ļƫͷʹЧ2448h40%Ļ³ͷʹʱ2ԿɴﵽͬЧʡڷƼЧԵƤ¸ҩЧͨ4hЧƤҩ4hƼԤٳͷʹƤҩ24hڳֵͷʹЧsumatriptanõԡ丱ͨͶݣʱ䳣45minڡע䲿λʹ졢ƸСȸСͷ衢ӡʹѡ׼ʱַԴزѹȸС

SaperܽӦsumatriptanע֤Ϊ>5560(Խ֤);;ȱѪļ(Ľʹļʷ¼֢״ȱѪ);ȶĽʹ;Ѫѹ(δ);ͻƫ̱ƫͷʹ;δʶĹIJ(ڸŮ>40꣬ಡΣѪѹ֬Ѫ֢֡򲡡̼ǿԼʷ);(ض);ͬʱӦõøҩ򵥰øҩֹ2;ͬʱӦúǰƼ(24h)״μҪҽ໤Ӧá

ʯǰЧʯǰЧѸ١СضȷرãҲƫͷʹʯǰйͬĻƣ䶯ѪýѡѪܵԣɾע䡢ע估ǻ롣ע;ҩЧѸ١עöȴ100%ǻľö40%ӦþʯǰٳͷʹƵʽеĿƫͷʹҩС˥ڳйء

ʯǰϾʯǰнϺõԡ寵ķʼ̶ȷdzͣעߣע估ҩ͡ٳͷʹͨĸðʹȼʹݵѪѹӦѪܾηӦĻߣ֪ΧԶ״(رDzȶĽʹѪܾĽʹ)δƵĸѪѹעͽ֤ͬʯǰ

3.ƫͷʹ

(1)ƫͷʹصǷҪƼƣĿǰ޶ۡͨΪԵġݵģδʱл⡣߾ԡصġԵףºƽ(ǵƽ)ͷʹпܼأЧ಻϶sumatriptanǰ(ʯǰ)Чд۲֮С

(2)ƫͷʹͷʹͷʹҪ漰ƫͷʹ״̬ͷʹΪһ⡣߳Ľչͷʹһϵ֢״ġŻ¡кˮɱҩȼ֢״ٷЩϰ໼߳뼱֢ҹ۲סԺԾߴڵϰˮ;ųƫͷʹֵصڿƻڿƼ;ƾҩ;ԤڼɱȡӦע⻼ߵĵͼ顣ҩѡþʯǰSumatriptanѻƬ༰ֹҩҪʱɽȱີȡѡ÷dz;ҩ羲עҩһƣ𽥼Ԥҩơ

(3)︾ŮƣSchulmanעƬӦƼӦɣ䲻״̥̣ڲ̥Ӧ̫ƵУþܲԤҩﲢӦƼ

(4)ڶͯƫͷʹͯƫͷʹҩѡкܶصֹʹҩͨ׿ҩ鰷ҩȣҲɾʯǰҩЧȷҪǶԶͯҳаοʹԱһȫʶԻɴ˴ĽǣƵ档

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